反应详情

Phosphorous oxychloride (6.0 ml) was added to a stirred mixture of 2-acetamido-5-hydroxy-1,8-naphthyridine (2.4 g, 11.8 mmol) and N,N-dimethylaniline (6.0 ml) in toluene (100 ml). The mixture was then heated at reflux for 1 hour. The mixture was allowed to cool, the tolulene was removed by evaporation and the residue was partitioned between methylene chloride and aqueous sodium hydrogen carbonate solution. The organic layer was separated, dried (MgSO4) and the solvent was removed by evaporation to give 2-acetamido-5-chloro-1,8-naphthyridine (470 mg, 18%) as a brown solid.

1. temperatureThe mixture was then heated
2. temperatureat reflux for 1 hour
3. temperatureto cool
4. customthe tolulene was removed by evaporation
5. customthe residue was partitioned between methylene chloride and aqueous sodium hydrogen carbonate solution
6. customThe organic layer was separated
7. dry with materialdried (MgSO4)
8. customthe solvent was removed by evaporation