反应详情

温度

50 °C

3-Methoxy-4-methoxycarbonylaniline (14.15 g, 78 mmol) was suspended in isopropanol and heated at 50° C. 2,2-Dimethyl-5-methoxymethylene-1,3-dioxane-4,6-dione (14.8 g, 80 mmol), (Montatsh. Chem. 1967, 98, 564), was then added in portions over 10 minutes and the mixture was heated at reflux for 30 minutes. The mixture was left to cool to ambient temperature overnight. The precipitate formed was collected by filtration, washed with isopropanol and dried under vacuum to give 5-((3-methoxy-4-methoxycarbonylanilino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione (25.2 g, 96%).

1. temperaturethe mixture was heated
2. temperatureat reflux for 30 minutes
3. waitThe mixture was left
4. temperatureto cool to ambient temperature overnight
5. customThe precipitate formed
6. filtrationwas collected by filtration
7. washwashed with isopropanol
8. customdried under vacuum