Ammonium formate → HCID 69740641, compound

HRID 393686Notes

Reaction equation

HRID 393686 reaction equation
C([O-])=O.[NH4+].[CH2:5]([NH:7][C:8]([N:10]1[CH:15]([C:16]2[N:17]=[CH:18][O:19][C:20]=2[C:21]2[CH:26]=[CH:25][C:24](Cl)=[CH:23][CH:22]=2)[C:14]([C:28]#[N:29])=[C:13]([CH3:30])[NH:12][C:11]1=[O:31])=[O:9])[CH3:6]>[Pd].C(#N)C>[CH2:5]([NH:7][C:8]([N:10]1[CH:15]([C:16]2[N:17]=[CH:18][O:19][C:20]=2[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:14]([C:28]#[N:29])=[C:13]([CH3:30])[NH:12][C:11]1=[O:31])=[O:9])[CH3:6]

Participants

5

Reactant 2

HCID 2723923Ammonium formateHCID 10134702HCID 10134702, compound

Product 1

HCID 69740641HCID 69740641, compoundYield 45%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 6342AcetonitrileSolvent

Procedure

Catalytic reduction (10% Pd/C, ammonium formate in refluxing acetonitrile) of the product of Example 99 gave the title compound in 45% yield.

Sources & evidence

ORD record
ord-9579f414013740f6ab0b2ed026909f4c
Source dataset
uspto-grants-2004_10
Patent number
US06809102B2

Reaction notes

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