2-[4-(4-furan-2-yl-phenyl)piperazine-1-sulfonylmethyl]-N-hydroxy-3-methylbutyramide → 4-[4-(4-Bromophenyl)piperazine-1-sulfonylmethyl]-tetrahydropyran-4-carboxylic acid hydroxyamide

HRID 393692Notes

Reaction equation

HRID 393692 reaction equation
O1C=CC=C1C1C=CC(N2CCN(S(CC(C(C)C)C([NH:25][OH:26])=O)(=O)=O)CC2)=CC=1.[Br:30][C:31]1[CH:36]=[CH:35][C:34]([N:37]2[CH2:42][CH2:41][N:40]([S:43]([CH2:46][C:47]3([C:53](O)=[O:54])[CH2:52][CH2:51][O:50][CH2:49][CH2:48]3)(=[O:45])=[O:44])[CH2:39][CH2:38]2)=[CH:33][CH:32]=1>>[OH:26][NH:25][C:53]([C:47]1([CH2:46][S:43]([N:40]2[CH2:39][CH2:38][N:37]([C:34]3[CH:35]=[CH:36][C:31]([Br:30])=[CH:32][CH:33]=3)[CH2:42][CH2:41]2)(=[O:44])=[O:45])[CH2:48][CH2:49][O:50][CH2:51][CH2:52]1)=[O:54]

Participants

3

Reactant 2

HCID 99319692-[4-(4-furan-2-yl-phenyl)piperazine-1-sulfonylmethyl]-N-hydroxy-3-methylbutyramideHCID 226466794-[4-(4-Bromophenyl)piperazine-1-sulfonylmethyl]tetrahydropyran-4-carboxylic acid

Product 1

HCID 865847694-[4-(4-Bromophenyl)piperazine-1-sulfonylmethyl]-tetrahydropyran-4-carboxylic acid hydroxyamideYield 87%

Procedure

Prepared according to the method for the preparation of 2-[4-(4-furan-2-yl-phenyl)piperazine-1-sulfonylmethyl]-N-hydroxy-3-methylbutyramide, from 4-[4-(4-bromophenyl)piperazine-1-sulfonylmethyl]tetrahydropyran-4-carboxylic acid (4.54 g), to yield the title compound as a white solid (4.07 g, 87%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-cd05d399e5d94fdeb3a9cffb1a9fb470
Source dataset
uspto-grants-2004_10
Patent number
US06809100B2

Reaction notes

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