反应详情

温度

80 °C

Iodine (42 g), triphenylphosphine (47 g) and imidazole (12 g) were added to a solution of 4-(R)-benzyl-3-(2-(R)-hydroxymethyl-3-methylbutyryl)oxazolidin-2-one (45 g) in toluene (400 ml) and the mixture was heated to 80° C. for 1 h, then cooled and washed with water and saturated brine. The solvent was dried (Na2SO4) and evaporated and the residue filtered through silica (200 g) eluting with diethyl ether-hexane 1:1 to give the title compound as a yellow viscous oil (56.4 g).

1. temperaturecooled
2. washwashed with water and saturated brine
3. dry with materialThe solvent was dried (Na2SO4)
4. customevaporated
5. filtrationthe residue filtered through silica (200 g)
6. washeluting with diethyl ether-hexane 1:1