5-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride → 4-[5-(4-Chlorophenyl)pyridin-2-yl]piperazine dihydrochloride

HRID 393708Notes

Reaction equation

HRID 393708 reaction equation
[ClH:1].Cl.FC1C=CC(C2C=NC(N3CCNCC3)=NC=2)=CC=1.C(OC([N:29]1[CH2:34][CH2:33][N:32]([C:35]2[CH:40]=[CH:39][C:38]([C:41]3[CH:46]=[CH:45][C:44]([Cl:47])=[CH:43][CH:42]=3)=[CH:37][N:36]=2)[CH2:31][CH2:30]1)=O)(C)(C)C>>[ClH:47].[ClH:1].[Cl:47][C:44]1[CH:43]=[CH:42][C:41]([C:38]2[CH:39]=[CH:40][C:35]([N:32]3[CH2:31][CH2:30][NH:29][CH2:34][CH2:33]3)=[N:36][CH:37]=2)=[CH:46][CH:45]=1

Participants

3

Reactant 2

HCID 226466725-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochlorideHCID 698953994-[5-(4-Chlorophenyl)pyridin-2-yl]piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 226467004-[5-(4-Chlorophenyl)pyridin-2-yl]piperazine dihydrochlorideYield 91%

Procedure

Prepared according to the method for the preparation of 5-(4-fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride, from 4-[5-(4-chlorophenyl)pyridin-2-yl]piperazine-1-carboxylic acid tert-butyl ester (0.570 g), to furnish the title compound as an off-white solid (0.478 g, 91%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-c217de683ffd466e85c5bdd810dae4c4
Source dataset
uspto-grants-2004_10
Patent number
US06809100B2

Reaction notes

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