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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 393708Generated: October 25, 2026

5-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride → 4-[5-(4-Chlorophenyl)pyridin-2-yl]piperazine dihydrochloride

https://huagongshe.com/reaction/393708

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochlorideHCID 22646672—
Reactant4-[5-(4-Chlorophenyl)pyridin-2-yl]piperazine-1-carboxylic acid tert-butyl esterHCID 69895399—
Product4-[5-(4-Chlorophenyl)pyridin-2-yl]piperazine dihydrochlorideHCID 2264670091%

Reaction Steps

Prepared according to the method for the preparation of 5-(4-fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride, from 4-[5-(4-chlorophenyl)pyridin-2-yl]piperazine-1-carboxylic acid tert-butyl ester (0.570 g), to furnish the title compound as an off-white solid (0.478 g, 91%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06809100B2
Source datasetuspto-grants-2004_10
ORD IDord-c217de683ffd466e85c5bdd810dae4c4
Source noteuspto-grants-2004_10