Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-[5-(4-Chlorophenyl)pyridin-2-yl]piperazine dihydrochloride → 4-(R)-Benzyl-3-(2-(R)-{4-[5-(4-chlorophenyl)pyridin-2-yl]piperazine-1-sulfonylmethyl}-3-methylbutyryl)-oxazolidin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-[5-(4-Chlorophenyl)pyridin-2-yl]piperazine dihydrochloride | HCID 22646700 | — |
| 반응물 | 4-(R)-benzyl-3-(2-(R)-chlorosulfonylmethyl-3 methylbutyryl)oxazolidin-2-one | HCID 22888284 | — |
| 반응물 | 2-[4-(4-Bromo-phenyl)piperazine-1-sulfonylmethyl]3-methylbutyric acid tert-butyl ester | HCID 69895250 | — |
| 생성물 | 4-(R)-Benzyl-3-(2-(R)-{4-[5-(4-chlorophenyl)pyridin-2-yl]piperazine-1-sulfonylmethyl}-3-methylbutyryl)-oxazolidin-2-one | HCID 23519750 | 81% |
반응 단계
Prepared according to the method for the preparation of 2-[4-(4-bromophenyl)-piperazine-1-sulfonylmethyl]-3-methyl-butyric acid tert-butyl ester, from 4-[5-(4-chlorophenyl)pyridin-2-yl]piperazine dihydrochloride (0.228 g) and 4-(R)-benzyl-3-(2-(R)-chlorosulfonylmethyl-3-methylbutyryl)oxazolidin-2-one(0.295 g), to yield the title compound as a yellow solid (0.325 g, 81%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06809100B2 |
| 출처 데이터셋 | uspto-grants-2004_10 |
| ORD ID | ord-ede4772b71674cdfbe7e07b74763bb2d |
| 출처 메모 | uspto-grants-2004_10 |