5-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride → 5-(3,4-Dichlorophenyl)-2-piperazin-1-yl-pyrimidine, dihydrochloride

HRID 393728Notes

Reaction equation

HRID 393728 reaction equation
[ClH:1].Cl.FC1C=CC(C2C=NC(N3CCNCC3)=NC=2)=CC=1.C(OC([N:29]1[CH2:34][CH2:33][N:32]([C:35]2[N:40]=[CH:39][C:38]([C:41]3[CH:46]=[CH:45][C:44]([Cl:47])=[C:43]([Cl:48])[CH:42]=3)=[CH:37][N:36]=2)[CH2:31][CH2:30]1)=O)(C)(C)C>>[ClH:47].[ClH:1].[Cl:48][C:43]1[CH:42]=[C:41]([C:38]2[CH:37]=[N:36][C:35]([N:32]3[CH2:31][CH2:30][NH:29][CH2:34][CH2:33]3)=[N:40][CH:39]=2)[CH:46]=[CH:45][C:44]=1[Cl:47]

Participants

3

Reactant 2

HCID 226466725-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochlorideHCID 698949894-[5-(3,4-Dichlorophenyl)pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 1317245825-(3,4-Dichlorophenyl)-2-piperazin-1-yl-pyrimidine, dihydrochlorideYield 90%

Procedure

Prepared according to the method for the preparation of 5-(4-fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride, from 4-[5-(3,4-Dichlorophenyl)pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl ester (0.93 g), to furnish the title compound as an off-white solid (0.78 g, 90%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-bccee48f997e420ca74532769db11ad7
Source dataset
uspto-grants-2004_10
Patent number
US06809100B2

Reaction notes

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