HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride → 5-(3,4-Dichlorophenyl)-2-piperazin-1-yl-pyrimidine, dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride | HCID 22646672 | — |
| Reactant | 4-[5-(3,4-Dichlorophenyl)pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl ester | HCID 69894989 | — |
| Product | 5-(3,4-Dichlorophenyl)-2-piperazin-1-yl-pyrimidine, dihydrochloride | HCID 131724582 | 90% |
Reaction Steps
Prepared according to the method for the preparation of 5-(4-fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride, from 4-[5-(3,4-Dichlorophenyl)pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl ester (0.93 g), to furnish the title compound as an off-white solid (0.78 g, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06809100B2 |
| Source dataset | uspto-grants-2004_10 |
| ORD ID | ord-bccee48f997e420ca74532769db11ad7 |
| Source note | uspto-grants-2004_10 |