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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 393731Generated: October 30, 2026

4-(Trifluoromethyl)phenylboronic acid → 4-[5-(4-Trifluoromethylphenyl)pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/393731

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethyl)phenylboronic acidHCID 2734389—
Reactanttert-Butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylateHCID 21914476—
ReactantTert-butyl 4-[5-(4-fluorophenyl)pyrimidin-2-yl]piperazine-1-carboxylateHCID 69850026—
Product4-[5-(4-Trifluoromethylphenyl)pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl esterHCID 6989480995%

Reaction Steps

Prepared according to the method for the preparation of 4-[5-(4-fluorophenyl)pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl ester, from 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylic acid tert-butyl ester (0.346 g) and 4-(trifluoromethyl)benzeneboronic acid (0.211 g), to yield the title compound as a grey solid (0.392 g, 95%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06809100B2
Source datasetuspto-grants-2004_10
ORD IDord-5335c99af6884d2a86ba1a01fc444d67
Source noteuspto-grants-2004_10