5-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride → 2-Piperazin-1-yl-5-(4-trifluoromethylphenyl)pyrimidine, dihydrochloride

HRID 393732Notes

Reaction equation

HRID 393732 reaction equation
[ClH:1].Cl.FC1C=CC(C2C=NC(N3CCNCC3)=NC=2)=CC=1.C(OC([N:29]1[CH2:34][CH2:33][N:32]([C:35]2[N:40]=[CH:39][C:38]([C:41]3[CH:46]=[CH:45][C:44]([C:47]([F:50])([F:49])[F:48])=[CH:43][CH:42]=3)=[CH:37][N:36]=2)[CH2:31][CH2:30]1)=O)(C)(C)C>>[ClH:1].[ClH:1].[N:32]1([C:35]2[N:36]=[CH:37][C:38]([C:41]3[CH:42]=[CH:43][C:44]([C:47]([F:49])([F:48])[F:50])=[CH:45][CH:46]=3)=[CH:39][N:40]=2)[CH2:33][CH2:34][NH:29][CH2:30][CH2:31]1

Participants

3

Reactant 2

HCID 226466725-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochlorideHCID 698948094-[5-(4-Trifluoromethylphenyl)pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 1317245832-Piperazin-1-yl-5-(4-trifluoromethylphenyl)pyrimidine, dihydrochlorideYield 69%

Procedure

Prepared according to the method for the preparation of 5-(4-fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride, from 4-[5-(4-trifluoromethylphenyl)pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl ester(0.392 g), to furnish the title compound as an off-white solid (0.250 g, 69%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-572789265b344a03bbc1627c2e50fa69
Source dataset
uspto-grants-2004_10
Patent number
US06809100B2

Reaction notes

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