HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride → 2-Piperazin-1-yl-5-(4-trifluoromethylphenyl)pyrimidine, dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride | HCID 22646672 | — |
| Reactant | 4-[5-(4-Trifluoromethylphenyl)pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl ester | HCID 69894809 | — |
| Product | 2-Piperazin-1-yl-5-(4-trifluoromethylphenyl)pyrimidine, dihydrochloride | HCID 131724583 | 69% |
Reaction Steps
Prepared according to the method for the preparation of 5-(4-fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride, from 4-[5-(4-trifluoromethylphenyl)pyrimidin-2-yl]piperazine-1-carboxylic acid tert-butyl ester(0.392 g), to furnish the title compound as an off-white solid (0.250 g, 69%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06809100B2 |
| Source dataset | uspto-grants-2004_10 |
| ORD ID | ord-572789265b344a03bbc1627c2e50fa69 |
| Source note | uspto-grants-2004_10 |