HRID393737

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22646672

未命名化合物

结构：CC(C)[C@@H](CS(=O)(=O)N1CCN(c2ncc(-c3ccc(F)cc3)cn2)CC1)C(=O)N1C(=O)OC[C@H]1Cc1ccccc1

HCID23519754

未命名化合物

HCID58947956

未命名化合物

PRODUCTS

生成物

结构：COC(=O)C1(CS(=O)(=O)N2CCN(c3ncc(-c4ccc(F)cc4)cn3)CC2)CCCCC1

HCID69894795

未命名化合物

收率 48%

PROCEDURE

实验过程

Prepared according to the method for the preparation of 4-(R)-benzyl-3-(2-(R)-{4-[5-(4-fluorophenyl)pyrimidin-2-yl]piperazine-1-sulfonylmethyl}-3-methyl-butyryl)oxazolidin-2-one, from 5-(4-fluorophenyl)-2-piperazine-1-ylpyrimidine, dihydrochloride (0.599 g) and 1-chlorosulfonylmethylcyclohexanecarboxylic acid methyl ester (0.575 g), to yield the title compound as a white solid (0.417 g, 48%).

WORKUP

后处理

customPrepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a8bc362f5ca041dfbd0c562610babff3
来源数据集: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06809100B2
来源说明: uspto-grants-2004_10

反应 SMILES

C([C@@H]1COC(=O)N1C(=O)[C@H]([CH2:19][S:20]([N:23]1[CH2:28][CH2:27][N:26]([C:29]2[N:34]=[CH:33][C:32]([C:35]3[CH:40]=[CH:39][C:38]([F:41])=[CH:37][CH:36]=3)=[CH:31][N:30]=2)[CH2:25][CH2:24]1)(=[O:22])=[O:21])C(C)C)C1C=CC=CC=1.Cl.Cl.FC1C=CC(C2C=NC(N3CCNCC3)=NC=2)=CC=1.[CH3:64][O:65][C:66]([C:68]1(CS(Cl)(=O)=O)[CH2:73][CH2:72][CH2:71][CH2:70][CH2:69]1)=[O:67]>>[CH3:64][O:65][C:66]([C:68]1([CH2:19][S:20]([N:23]2[CH2:24][CH2:25][N:26]([C:29]3[N:34]=[CH:33][C:32]([C:35]4[CH:36]=[CH:37][C:38]([F:41])=[CH:39][CH:40]=4)=[CH:31][N:30]=3)[CH2:27][CH2:28]2)(=[O:22])=[O:21])[CH2:73][CH2:72][CH2:71][CH2:70][CH2:69]1)=[O:67]