Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride → 1-{4-[5-(4-Fluorophenyl)pyrimidin-2-yl]piperazine-1-sulfonylmethyl}cyclohexanecarboxylic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride | HCID 22646672 | — |
| 반응물 | 4-(R)-benzyl-3(2-(R)-{4-[5-(4-fluorophenyl)pyrimidin-2-yl)piperazine-1-sulfonylmethyl}-3-methylbutyryl)oxazolidin-2-one | HCID 23519754 | — |
| 반응물 | 1-Chlorosulfonylmethylcyclohexanecarboxylic acid methyl ester | HCID 58947956 | — |
| 생성물 | 1-{4-[5-(4-Fluorophenyl)pyrimidin-2-yl]piperazine-1-sulfonylmethyl}cyclohexanecarboxylic acid methyl ester | HCID 69894795 | 48% |
반응 단계
Prepared according to the method for the preparation of 4-(R)-benzyl-3-(2-(R)-{4-[5-(4-fluorophenyl)pyrimidin-2-yl]piperazine-1-sulfonylmethyl}-3-methyl-butyryl)oxazolidin-2-one, from 5-(4-fluorophenyl)-2-piperazine-1-ylpyrimidine, dihydrochloride (0.599 g) and 1-chlorosulfonylmethylcyclohexanecarboxylic acid methyl ester (0.575 g), to yield the title compound as a white solid (0.417 g, 48%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06809100B2 |
| 출처 데이터셋 | uspto-grants-2004_10 |
| ORD ID | ord-a8bc362f5ca041dfbd0c562610babff3 |
| 출처 메모 | uspto-grants-2004_10 |