5-(4-Chlorophenyl)-2-piperidin-4-ylpyrimidine → 4-(R)-Benzyl-3-(2-(R)-{4-[5-(4-chlorophenyl)pyrimidin-2-yl]piperazine-1-sulfonylmethyl}-3-methylbutyryl)-oxazolidin-2-one

참여 물질

역할	이름	HCID	투입량
반응물	5-(4-Chlorophenyl)-2-piperidin-4-ylpyrimidine	HCID 22646697	—
반응물	4-(R)-benzyl-3-(2-(R)-chlorosulfonylmethyl-3 methylbutyryl)oxazolidin-2-one	HCID 22888284	—
반응물	4-(R)-benzyl-3(2-(R)-{4-[5-(4-fluorophenyl)pyrimidin-2-yl)piperazine-1-sulfonylmethyl}-3-methylbutyryl)oxazolidin-2-one	HCID 23519754	—
생성물	4-(R)-Benzyl-3-(2-(R)-{4-[5-(4-chlorophenyl)pyrimidin-2-yl]piperazine-1-sulfonylmethyl}-3-methylbutyryl)-oxazolidin-2-one	HCID 23532150	100%

반응 단계

Prepared according to the method for the preparation of 4-(R)-benzyl-3-(2-(R)-{4-[5-(4-fluorophenyl)pyrimidin-2-yl]piperazine-1-sulfonylmethyl}-3-methyl-butyryl)oxazolidin-2-one, from 5-(4-chlorophenyl)-2-piperidin-4-ylpyrimidine (0.123 g) and 4-(R)-benzyl-3-(2-(R)-chlorosulfonylmethyl-3-methylbutyryl)-oxazolidin-2-one (0.269 g), to yield the title compound as a cream foam (0.275 g, 100%).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06809100B2
출처 데이터셋	uspto-grants-2004_10
ORD ID	ord-febf31f1700f4511a645693c0051f21f
출처 메모	uspto-grants-2004_10