反应详情

温度

20 °C

In a 250 ml flask containing 80 ml of THF, under an argon atmosphere, 2.45 g (9.8 mmoles) of 3,5-di-tert-butyl-4-hydroxybenzoic acid, 1.8 g (10.8 mmoles) of 4-nitrobenzene-ethanol and 2.2 g (10.8 mmoles) of dicyclohexylcarbodiimide are introduced successively, under agitation. The reaction medium is agitated for 15 hours at 20° C. and the precipitate which appears is filtered out. The filtrate is washed with 2×30 ml of a saturated NaCl solution, the organic phase is dried over magnesium sulphate, filtered and concentrated under vacuum. The residue is then crystallized using di-isopropyl ether. The solid is recovered by filtration and 2.4 g (62%) of white crystals are obtained after drying. Melting point: 123.5-124.5° C.

1. filtrationthe precipitate which appears is filtered out
2. washThe filtrate is washed with 2×30 ml of a saturated NaCl solution
3. dry with materialthe organic phase is dried over magnesium sulphate
4. filtrationfiltered
5. concentrationconcentrated under vacuum
6. customThe residue is then crystallized
7. filtrationThe solid is recovered by filtration and 2.4 g (62%) of white crystals
8. customare obtained
9. customafter drying