反应详情

温度

50 °C

5-(5-Acetyl-2-butoxy-3-pyridinyl)-3-ethyl-2-(1-ethyl-3-azetidinyl)-2,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one (88 mg, 0.2 mmol) was dissolved in warm ethyl acetate (2 mL). A solution of benzenesulfonic acid (32 mg, 0.2 mmol) in ethyl acetate (2 ml) was then added, giving a precipitate. This mixture was warmed to 50° C. for 15 minutes, then allowed to cool to 0° C. The resulting solid was filtered, washed with ethyl acetate and dried in vacuo, to afford the title compound as a white solid 89 mg (74%).

1. customgiving a precipitate
2. temperatureto cool to 0° C
3. filtrationThe resulting solid was filtered
4. washwashed with ethyl acetate
5. customdried in vacuo