Sodium 1-tert-butyl tetrazole-5-thiolate → HCID 67606045, compound

HRID 39403Notes

Reaction equation

HRID 39403 reaction equation
[C:1]([N:5]1[C:9]([S-:10])=[N:8][N:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[Na+].Cl[CH2:13][C@H:14]1[O:19][C:18]([CH3:21])([CH3:20])[O:17][C@@H:16]([CH2:22][C:23]([O:25][C:26]([CH3:35])([CH3:34])[CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[O:24])[CH2:15]1>>[C:1]([N:5]1[C:9]([S:10][CH2:13][C@H:14]2[O:19][C:18]([CH3:20])([CH3:21])[O:17][C@@H:16]([CH2:22][C:23]([O:25][C:26]([CH3:34])([CH3:35])[CH2:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)=[O:24])[CH2:15]2)=[N:8][N:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 44598020Sodium 1-tert-butyl tetrazole-5-thiolateHCID 676077022-methyl-1-phenylpropan-2-yl 2-((4R,6S)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

Product 1

HCID 67606045HCID 67606045, compound

Procedure

The procedure was carried out in the same manner as in Example 11, except that sodium 1-tert-butyl tetrazole-5-thiolate (3.6 g) prepared in Example 8 was used in place of sodium 1-phenyl-1H-tetrazole-5-thiolate, and 3.5 g of 2-methyl-1-phenylpropan-2-yl 2-((4R,6S)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate was used in place of 30 g thereof. The title compound was obtained (4.6 g).

Sources & evidence

ORD record
ord-abc27bb531384fe695337607a40f3259
Source dataset
uspto-grants-2013_09
Patent number
US08524914B2

Reaction notes

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