Iodoethane → HCID 69101340, compound

HRID 394033Notes

Reaction equation

HRID 394033 reaction equation
[OH:1][C@H:2]1[CH2:6][N:5]([C:7](=[O:34])[CH2:8][C:9]([C:26]2[CH:31]=[CH:30][C:29]([CH2:32][CH3:33])=[CH:28][CH:27]=2)([C:18]2[CH:23]=[CH:22][C:21]([CH2:24][CH3:25])=[CH:20][CH:19]=2)[C:10]2[CH:15]=[CH:14][C:13]([CH2:16][CH3:17])=[CH:12][CH:11]=2)[C@H:4]([C:35]([N:37]2[CH2:41][CH2:40][CH2:39][C@@H:38]2[C:42]([NH:44][CH2:45][C@H:46]2[CH2:51][CH2:50][CH2:49][NH:48][CH2:47]2)=[O:43])=[O:36])[CH2:3]1.[CH2:52](I)[CH3:53]>>[CH2:52]([N:48]1[CH2:49][CH2:50][CH2:51][C@H:46]([CH2:45][NH:44][C:42]([C@H:38]2[CH2:39][CH2:40][CH2:41][N:37]2[C:35]([C@@H:4]2[CH2:3][C@@H:2]([OH:1])[CH2:6][N:5]2[C:7](=[O:34])[CH2:8][C:9]([C:18]2[CH:19]=[CH:20][C:21]([CH2:24][CH3:25])=[CH:22][CH:23]=2)([C:10]2[CH:11]=[CH:12][C:13]([CH2:16][CH3:17])=[CH:14][CH:15]=2)[C:26]2[CH:31]=[CH:30][C:29]([CH2:32][CH3:33])=[CH:28][CH:27]=2)=[O:36])=[O:43])[CH2:47]1)[CH3:53]

Participants

3

Reactant 2

HCID 6340IodoethaneHCID 69100635HCID 69100635, compound

Product 1

HCID 69101340HCID 69101340, compound

Procedure

The title compound was prepared by a method similar to Example 77, using (2R)-1-((2S,4R)-4-hydroxy-1-{3,3,3-tris(4-ethylphenyl)propanoyl}pyrrolidin-2-yl)carbonyl-N-{((3S)-3-piperidyl)methyl}pyrrolidine-2-carboxamide and ethyl iodide. The compound was obtained as a white solid.

Workup

  1. customThe compound was obtained as a white solid

Sources & evidence

ORD record
ord-6cca44db16d24a61baa4a8ccd1fd5d3b
Source dataset
uspto-grants-2004_10
Patent number
US06809108B1

Reaction notes

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