Bromomethylcyclopropane → HCID 69100644, compound

HRID 394040Notes

Reaction equation

HRID 394040 reaction equation
[CH:1]1([CH2:4][N:5]2[CH2:10][CH2:9][CH2:8][C@@H:7]([CH2:11][NH:12][C:13]([C@H:15]3[CH2:19][CH2:18][CH2:17][N:16]3[C:20]([C@@H:22]3[CH2:26][C@@H:25]([OH:27])[CH2:24][N:23]3[C:28](=[O:49])[CH2:29][C:30]([C:43]3[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=3)([C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)[C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)=[O:21])=[O:14])[CH2:6]2)[CH2:3][CH2:2]1.[CH:50]1([CH2:53][Br:54])[CH2:52][CH2:51]1>>[Br-:54].[CH:1]1([CH2:4][N+:5]2([CH2:53][CH:50]3[CH2:52][CH2:51]3)[CH2:10][CH2:9][CH2:8][C@@H:7]([CH2:11][NH:12][C:13]([C@H:15]3[CH2:19][CH2:18][CH2:17][N:16]3[C:20]([C@@H:22]3[CH2:26][C@@H:25]([OH:27])[CH2:24][N:23]3[C:28](=[O:49])[CH2:29][C:30]([C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)([C:31]3[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=3)[C:43]3[CH:44]=[CH:45][CH:46]=[CH:47][CH:48]=3)=[O:21])=[O:14])[CH2:6]2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 81503BromomethylcyclopropaneHCID 10484521HCID 10484521, compound

Product 1

HCID 69100644HCID 69100644, compound

Procedure

The title compound was prepared by a method similar to Example 130, using (2R)-N-{((3S)-1-cyclopropylmethyl-3-piperidyl)methyl}-1-{(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonylpyrrolidine-2-carboxamide and cyclopropylmethyl bromide. The compound was obtained as a white solid.

Workup

  1. customThe compound was obtained as a white solid

Sources & evidence

ORD record
ord-4409fdbaf4f74090a95091fdbec6caca
Source dataset
uspto-grants-2004_10
Patent number
US06809108B1

Reaction notes

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