Bromomethylcyclopropane → HCID 69101135, compound

HRID 394042Notes

Reaction equation

[CH2:1]([N:5]1[CH2:10][CH2:9][CH2:8][C@H:7]([CH2:11][NH:12][C:13]([C@H:15]2[CH2:19][CH2:18][CH2:17][N:16]2[C:20]([C@@H:22]2[CH2:26][C@@H:25]([OH:27])[CH2:24][N:23]2[C:28](=[O:49])[CH2:29][C:30]([C:43]2[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=2)([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[O:21])=[O:14])[CH2:6]1)[CH2:2][CH2:3][CH3:4].[Br:50][CH2:51]C1CC1>>[Br-:50].[CH2:1]([N+:5]1([CH3:51])[CH2:10][CH2:9][CH2:8][C@H:7]([CH2:11][NH:12][C:13]([C@H:15]2[CH2:19][CH2:18][CH2:17][N:16]2[C:20]([C@@H:22]2[CH2:26][C@@H:25]([OH:27])[CH2:24][N:23]2[C:28](=[O:49])[CH2:29][C:30]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)([C:43]2[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=2)[C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[O:21])=[O:14])[CH2:6]1)[CH2:2][CH2:3][CH3:4]

Participants

Reactant 2

HCID 81503Bromomethylcyclopropane

HCID 69100773HCID 69100773, compound

Product 1

HCID 69101135HCID 69101135, compound

Procedure

The title compound was prepared by a method similar to Example 128, using (2R)-N-{((3R)-1-butyl-3-piperidyl)methyl}-1-{(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonylpyrrolidine-2-carboxamide and (bromomethyl)cyclopropane. The compound was obtained as a white foamy substance.

Workup

customThe compound was obtained as a white foamy substance

Sources & evidence

ORD record: ord-f399a6d66d554b8fab1b17afd16116f0
Source dataset: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06809108B1

Reaction notes

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