HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → Ethyl (3S)-piperidine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl (S)-3-Piperidinecarboxylate D-Tartrate | HCID 14183617 | — |
| Product | Ethyl (3S)-piperidine-3-carboxylate | HCID 187784 | 112.8% |
Reaction Steps
To 13.0 g of ethyl (3S)-3-piperidinecarboxylate D(−)-tartarate which was synthesized following the method of P. Magnus, et al. [J. Org. Chem. Vol. 56, 1166-1170 (1991)], 3N aqueous sodium hydroxide solution was added to render the former basic, followed by extraction with chloroform and drying over anhydrous magnesium sulfate. Distilling the solvent off under reduced pressure, 7.50 g of the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06809108B1 |
| Source dataset | uspto-grants-2004_10 |
| ORD ID | ord-2634489c1dd6442fbb237c8936f4cd17 |
| Source note | uspto-grants-2004_10 |