反应详情

5-(2-Chlorophenyl)-1-(2,6-dichlorophenyl)-7-methoxy-2(1H)-quinolinone was prepared from 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3,4-dihydro-7-methoxy-2(1H)-quinolinone (INTERMEDIATE 6), N-bromosuccinimide, and 2,2′-azobis(2-methylpropionitrile) by a procedure analogous to that described in INTERMEDIATE 4. Mass spectrum (ESI) 430.0 (M+1). 1H NMR (500 MHz, CDCl3): δ 7.53-7.62 (m, 3H); 7.30-7.49 (m, 5H); 6.77 (d, J=2.0 Hz, 1H); 6.61 (d, J=9.5 Hz, 1H); 6.03 (d, J=2.5 Hz, 1H); 3.74 (s, 3H).