Morpholine → HCID 22648041, compound

HRID 394122Notes

Reaction equation

Br[CH2:2][C:3]([C:5]1[CH:14]=[C:13]2[C:8]([CH2:9][N:10](CC3C=CC(OC)=CC=3)[C:11](=[O:23])[N:12]2[C:15]2[C:20]([Cl:21])=[CH:19][CH:18]=[CH:17][C:16]=2[Cl:22])=[C:7]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=2[Cl:39])[CH:6]=1)=[O:4].[NH:40]1[CH2:45][CH2:44]O[CH2:42][CH2:41]1>>[Cl:39][C:34]1[CH:35]=[CH:36][CH:37]=[CH:38][C:33]=1[C:7]1[CH:6]=[C:5]([C:3](=[O:4])[CH2:2][N:40]2[CH2:45][CH2:44][N:12]([CH:13]([CH3:14])[CH3:8])[CH2:42][CH2:41]2)[CH:14]=[C:13]2[C:8]=1[CH2:9][NH:10][C:11](=[O:23])[N:12]2[C:15]1[C:16]([Cl:22])=[CH:17][CH:18]=[CH:19][C:20]=1[Cl:21]

Participants

Reactant 2

HCID 8083Morpholine

HCID 22647971HCID 22647971, compound

Product 1

HCID 22648041HCID 22648041, compound

Procedure

The title compound was prepared from 7-(bromoacetyl)-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-3,4-dihydroquinazolin-2(1H)-one and using morpholine as an amine as described in EXAMPLE ABA1. 1H NMR (CDCl3, 500MHz): δ 7.53-7.27 (m, 8H); 6.92 (s, 1H); 5.91 (brs, 1H); 4.45 (d, J=15.5 Hz, 1H); 4.28 (d, J=15.5 Hz, 1H); 3.64 (m, 4H); 3.55 (Abq, J=3.7, 15.8 Hz, 2H); 2.44 (m, 4H). Mass spectrum (ESI): 530 (M+1).

Sources & evidence

ORD record: ord-f29cfaa41c474cb59e9627cc61ca6b07
Source dataset: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06809199B2

Reaction notes

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