Trifluoroacetic acid → HCID 22647944, compound

HRID 394162Notes

Reaction equation

HRID 394162 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:17]=[C:16]([O:18][CH:19]2[CH2:23][CH2:22][N:21](C(OCC3C=CC=CC=3)=O)[CH2:20]2)[CH:15]=[C:14]2[C:9]=1[CH2:10][CH2:11][C:12](=[O:42])[N:13]2[C:34]1[C:39]([Cl:40])=[CH:38][CH:37]=[CH:36][C:35]=1[Cl:41].C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:17]=[C:16]([O:18][CH:19]2[CH2:23][CH2:22][NH:21][CH2:20]2)[CH:15]=[C:14]2[C:9]=1[CH2:10][CH2:11][C:12](=[O:42])[N:13]2[C:34]1[C:35]([Cl:41])=[CH:36][CH:37]=[CH:38][C:39]=1[Cl:40]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22648146HCID 22648146, compound

Product 1

HCID 22647944HCID 22647944, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of benzyl 3-([5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl]oxy}pyrrolidine-1-carboxylate (0.051 g) in 6 mL of CH2Cl2 was added 1 mL of TFA and the mixture was stirred for 1 h at rt. The reaction mixture was purified by preparative thin layer chromatography eluting with 10% ethanol/dichloromethane to give the product. Mass spectrum m/z (ESI) 487.15 (M+1).

Workup

  1. customThe reaction mixture was purified by preparative thin layer chromatography
  2. washeluting with 10% ethanol/dichloromethane
  3. customto give the product

Sources & evidence

ORD record
ord-17f8e5cba06444d490bb39178b8cac21
Source dataset
uspto-grants-2004_10
Patent number
US06809199B2

Reaction notes

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