HRID394198

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID15410

Propanesulfonyl chloride, chloro-

C3H6Cl2O2S

结构：COc1ccc(CN2Cc3c(-c4ccccc4Cl)cc(N)cc3N(c3c(Cl)cccc3Cl)C2=O)cc1

HCID22648015

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(CN2Cc3c(-c4ccccc4Cl)cc(NS(=O)(=O)CCCCl)cc3N(c3c(Cl)cccc3Cl)C2=O)cc1

HCID22647935

未命名化合物

PROCEDURE

实验过程

The 3-chloro-N-[5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydroquinazolin-7-yl]propane-1-sulfonamide was prepared from 7-amino-5-(2chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-3,4-dihydroquinazolin-2(1H)-one (COMPOUND CCC4, STEP A) and 3-chloropropane-1-sulfonyl chloride by a procedure analogous to that described in COMPOUND CCC5, STEP A: Mass spectrum (ESI) 678.1 (M+1).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-83e04b21d0894f3e8d77a9dbdcace5e5
来源数据集: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06809199B2
来源说明: uspto-grants-2004_10

反应 SMILES

[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][N:7]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=3)[C:8](=[O:20])[N:9]2[C:12]2[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:19])=[C:4]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=2[Cl:36])[CH:3]=1.[Cl:37][CH2:38][CH2:39][CH2:40][S:41](Cl)(=[O:43])=[O:42]>>[Cl:37][CH2:38][CH2:39][CH2:40][S:41]([NH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][N:7]([CH2:21][C:22]3[CH:23]=[CH:24][C:25]([O:28][CH3:29])=[CH:26][CH:27]=3)[C:8](=[O:20])[N:9]2[C:12]2[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:19])=[C:4]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=2[Cl:36])[CH:3]=1)(=[O:43])=[O:42]