反应详情

温度

80 °C

Methyl 3,5-dibromo-4-{(1Z)-3-[(2,6-dichlorophenyl)amino]-3-oxoprop-1-enyl}benzoate (1.25 g)(contaminated with 20% of the E isomer) was dissolved in dimethylformamide(36 mL) and the solution degassed with argon. Copper (I) iodide (340 mg) and dry potassium carbonate (468 mg) were added and the mixture heated to 80° C. for 30 min. The reaction mixture was poured into 5% ammonium hydroxide solution and extracted into ethyl acetate, dried over MgSO4 and concentrated. The residue was purified by silica gel chromatography eluting with 80% hexane: 20% ethyl acetate to give the title compound.

1. customthe solution degassed with argon
2. additionCopper (I) iodide (340 mg) and dry potassium carbonate (468 mg) were added
3. additionThe reaction mixture was poured into 5% ammonium hydroxide solution
4. extractionextracted into ethyl acetate
5. dry with materialdried over MgSO4
6. concentrationconcentrated
7. customThe residue was purified by silica gel chromatography
8. washeluting with 80% hexane