Lithium Hydroxide → HCID 10320564, compound

HRID 394244Notes

Reaction equation

HRID 394244 reaction equation
C([O:3][C:4](=[O:31])[CH:5]([O:28][CH2:29][CH3:30])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]2[N:16]=[C:17]([C:20]3[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=3)[S:18][CH:19]=2)=[CH:9][C:8]=1[CH3:27])C.[Li+].[OH-]>>[Cl:26][C:23]1[CH:24]=[CH:25][C:20]([C:17]2[S:18][CH:19]=[C:15]([CH2:14][O:13][C:10]3[CH:11]=[CH:12][C:7]([CH2:6][CH:5]([O:28][CH2:29][CH3:30])[C:4]([OH:31])=[O:3])=[C:8]([CH3:27])[CH:9]=3)[N:16]=2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 68618261HCID 68618261, compound

Product 1

HCID 10320564HCID 10320564, compound

Procedure

In analogy to the procedure described in example 10 d], [rac]-3-{4-[2-(4-chloro-phenyl)-thiazol-4-ylmethoxy]-2-methyl-phenyl}-2-ethoxy-propionic acid ethyl ester was treated with LiOH to obtain [rac]-3-{4-[2-(4-chloro-phenyl)-thiazol-4-ylmethoxy]-2-methyl-phenyl}-2-ethoxy-propionic acid as light yellow liquid.

Workup

  1. customdescribed in example 10 d

Sources & evidence

ORD record
ord-31d74a761a9b41f9a93971b2fb797b31
Source dataset
uspto-grants-2004_10
Patent number
US06809110B2

Reaction notes

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