反应详情

2-Fluoro-4,6-bis(trifluoromethyl)benzaldehyde (10 g, 38 mmol) was dissolved in 30 mL toluene. p-Toluenesulfonic acid (140 mg, 0.74 mmol) and N-butylamine (2.94 g, 40 mmol) were added. The reaction mixture was refluxed overnight. The mixture was extracted with 2N sodium carbonate solution and ethyl acetate. The combined organic phases were dried on sodium sulfate, filtered and evaporated. The crude material, orange oil (12 g, >100%) was used without further purification.

1. temperatureThe reaction mixture was refluxed overnight
2. extractionThe mixture was extracted with 2N sodium carbonate solution and ethyl acetate
3. customThe combined organic phases were dried on sodium sulfate
4. filtrationfiltered
5. customevaporated
6. customThe crude material, orange oil (12 g, >100%) was used without further purification