Lithium Hydroxide → [Rac]-2-ethoxy-3-[2-methyl-4-(2-phenyl-thiazol-4-ylmethoxy)-phenyl]-propionic acid

HRID 394281Notes

Reaction equation

HRID 394281 reaction equation
C([O:3][C:4](=[O:30])[CH:5]([O:27][CH2:28][CH3:29])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]2[N:16]=[C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[S:18][CH:19]=2)=[CH:9][C:8]=1[CH3:26])C.[Li+].[OH-]>>[CH2:28]([O:27][CH:5]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]2[N:16]=[C:17]([C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)[S:18][CH:19]=2)=[CH:9][C:8]=1[CH3:26])[C:4]([OH:30])=[O:3])[CH3:29]

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 68618354[Rac]-2-ethoxy-3-[2-methyl-4-(2-phenyl-thiazol-4-ylmethoxy)-phenyl]-propionic acid ethyl ester

Product 1

HCID 22647445[Rac]-2-ethoxy-3-[2-methyl-4-(2-phenyl-thiazol-4-ylmethoxy)-phenyl]-propionic acid

Procedure

In analogy to the procedure described in example 10 d], [rac]-2-ethoxy-3-[2-methyl-4-(2-phenyl-thiazol-4-ylmethoxy)-phenyl]-propionic acid ethyl ester was treated with LiOH to obtain [rac]-2-ethoxy-3-[2-methyl-4-(2-phenyl-thiazol-4-ylmethoxy)-phenyl]-propionic acid as colorless crystals.

Workup

  1. customdescribed in example 10 d

Sources & evidence

ORD record
ord-7b86e034796e47d789dc14a2e3ca9431
Source dataset
uspto-grants-2004_10
Patent number
US06809110B2

Reaction notes

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