反应详情

Crude butyl-[1-(2-cyclopropyl-4,6-bis-trifluoromethyl-phenyl)-methylidene]-amine (intermediate M, 3.54 g, 10.5 mmol) was dissolved in 8 mL water. Hydrochloric acid (25%, 0.49 mL) was added and the mixture was refluxed for 2 h. The mixture was extracted three times with ethyl acetate. The combined organic phases were dried on sodium sulfate, filtered and evaporated. The crude material, brown oil (1.01 g, 34%) was used without further purification.

1. temperaturethe mixture was refluxed for 2 h
2. extractionThe mixture was extracted three times with ethyl acetate
3. customThe combined organic phases were dried on sodium sulfate
4. filtrationfiltered
5. customevaporated
6. customThe crude material, brown oil (1.01 g, 34%) was used without further purification