Lithium Hydroxide → HCID 22647516, compound

HRID 394336Notes

Reaction equation

C([O:3][C:4](=[O:33])[CH:5]([O:30][CH2:31][CH3:32])[CH2:6][C:7]1[C:12]2[CH2:13][CH2:14][O:15][C:11]=2[C:10]([O:16][CH2:17][C:18]2[N:19]=[C:20]([C:23]3[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=3)[S:21][CH:22]=2)=[CH:9][CH:8]=1)C.[Li+].[OH-]>>[Cl:29][C:26]1[CH:27]=[CH:28][C:23]([C:20]2[S:21][CH:22]=[C:18]([CH2:17][O:16][C:10]3[C:11]4[O:15][CH2:14][CH2:13][C:12]=4[C:7]([CH2:6][CH:5]([O:30][CH2:31][CH3:32])[C:4]([OH:33])=[O:3])=[CH:8][CH:9]=3)[N:19]=2)=[CH:24][CH:25]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 68617589HCID 68617589, compound

Product 1

HCID 22647516HCID 22647516, compound

Procedure

In analogy to the procedure described in example 10 d], [rac]-3-{7-[2-(4-chloro-phenyl)-thiazol-4-ylmethoxy]-2,3-dihydro-benzofuran-4-yl}-2-ethoxy-propionic acid ethyl ester was treated with LiOH to obtain [rac]-3-{7-[2-(4-chloro-phenyl)-thiazol-4-ylmethoxy]-2,3-dihydro-benzofuran-4-yl}-2-ethoxy-propionic acid as colorless oil.

Workup

customdescribed in example 10 d

Sources & evidence

ORD record: ord-b989cc5079cd4f9697b617f0523562f9
Source dataset: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06809110B2

Reaction notes

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