Lithium Hydroxide → HCID 22647463, compound

HRID 394337Notes

Reaction equation

C[O:2][C:3](=[O:32])[CH:4]([O:29][CH2:30][CH3:31])[CH2:5][C:6]1[C:11]2[CH:12]=[CH:13][O:14][C:10]=2[C:9]([O:15][CH2:16][C:17]2[N:18]=[C:19]([C:22]3[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=3)[S:20][CH:21]=2)=[CH:8][CH:7]=1.[Li+].[OH-]>>[Cl:28][C:25]1[CH:26]=[CH:27][C:22]([C:19]2[S:20][CH:21]=[C:17]([CH2:16][O:15][C:9]3[C:10]4[O:14][CH:13]=[CH:12][C:11]=4[C:6]([CH2:5][CH:4]([O:29][CH2:30][CH3:31])[C:3]([OH:32])=[O:2])=[CH:7][CH:8]=3)[N:18]=2)=[CH:23][CH:24]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 68616057HCID 68616057, compound

Product 1

HCID 22647463HCID 22647463, compound

Procedure

In analogy to the procedure described in example 10 d], [rac]-3-{7-[2-(4-chloro-phenyl)-thiazol-4-ylmethoxy]-benzofuran-4-yl}-2-ethoxy-propionic acid methyl ester was treated with LiOH to obtain [rac]-3-{7-[2-(4-chloro-phenyl)-thiazol-4-ylmethoxy]-benzofuran-4-yl}-2-ethoxy-propionic acid as colorless solid.

Workup

customdescribed in example 10 d

Sources & evidence

ORD record: ord-51094fc7d0744921873a6f93d4863f26
Source dataset: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06809110B2

Reaction notes

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