Lithium Hydroxide → HCID 22647610, compound

HRID 394339Notes

Reaction equation

C([O:3][C:4](=[O:31])[CH:5]([O:28][CH2:29][CH3:30])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]2[N:16]=[C:17]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[S:18][C:19]=2[CH3:20])=[CH:9][C:8]=1[CH3:27])C.[Li+].[OH-]>>[CH2:29]([O:28][CH:5]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]2[N:16]=[C:17]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[S:18][C:19]=2[CH3:20])=[CH:9][C:8]=1[CH3:27])[C:4]([OH:31])=[O:3])[CH3:30]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 68618353HCID 68618353, compound

Product 1

HCID 22647610HCID 22647610, compound

Procedure

In analogy to the procedure described in example 10 d], [rac]-2-ethoxy-3-[2-methyl-4-(5-methyl-2-phenyl-thiazol-4-ylmethoxy)-phenyl]-propionic acid ethyl ester was treated with LiOH to obtain [rac]-2-ethoxy-3-[2-methyl-4-(5-methyl-2-phenyl-thiazol-4-ylmethoxy)-phenyl]-propionic acid as colorless liquid.

Workup

customdescribed in example 10 d

Sources & evidence

ORD record: ord-93e175cca56f47e4bea8bd12d0e0d7ee
Source dataset: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06809110B2

Reaction notes

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