Lithium Hydroxide → HCID 22647491, compound

HRID 394345Notes

Reaction equation

HRID 394345 reaction equation
C([O:3][C:4](=[O:33])[CH:5]([O:30][CH2:31][CH3:32])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][C:16]2[N:17]=[C:18]([C:21]3[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=3)[S:19][CH:20]=2)=[CH:9][C:8]=1[CH3:29])C.[Li+].[OH-]>>[CH2:31]([O:30][CH:5]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][C:16]2[N:17]=[C:18]([C:21]3[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=3)[S:19][CH:20]=2)=[CH:9][C:8]=1[CH3:29])[C:4]([OH:33])=[O:3])[CH3:32]

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 68616499HCID 68616499, compound

Product 1

HCID 22647491HCID 22647491, compound

Procedure

In analogy to the procedure described in example 10 d], [rac]-2-ethoxy-3-(4-{2-[2-(4-methoxy-phenyl)-thiazol-4-yl]-ethoxy}-2-methyl-phenyl)-propionic acid ethyl ester was treated with LiOH to obtain [rac]-2-ethoxy-3-(4-{2-[2-(4-methoxy-phenyl)-thiazol-4-yl]-ethoxy}-2-methyl-phenyl)-propionic acid as colorless liquid.

Workup

  1. customdescribed in example 10 d

Sources & evidence

ORD record
ord-bdabc5d68ae4486ea7933dc407ec53b4
Source dataset
uspto-grants-2004_10
Patent number
US06809110B2

Reaction notes

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