Lithium Hydroxide → HCID 22647574, compound

HRID 394350Notes

Reaction equation

C([O:3][C:4](=[O:37])[CH:5]([O:34][CH2:35][CH3:36])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16][C:17]2[N:18]=[C:19]([C:23]3[CH:28]=[CH:27][C:26]([C:29]([CH3:32])([CH3:31])[CH3:30])=[CH:25][CH:24]=3)[S:20][C:21]=2[CH3:22])=[CH:9][C:8]=1[CH3:33])C.[Li+].[OH-]>>[C:29]([C:26]1[CH:25]=[CH:24][C:23]([C:19]2[S:20][C:21]([CH3:22])=[C:17]([CH2:16][CH2:15][CH2:14][O:13][C:10]3[CH:11]=[CH:12][C:7]([CH2:6][CH:5]([O:34][CH2:35][CH3:36])[C:4]([OH:37])=[O:3])=[C:8]([CH3:33])[CH:9]=3)[N:18]=2)=[CH:28][CH:27]=1)([CH3:32])([CH3:30])[CH3:31]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 68616246HCID 68616246, compound

Product 1

HCID 22647574HCID 22647574, compound

Procedure

In analogy to the procedure described in example 10 d], [rac]-3-(4-{3-[2-(4-tert-butyl-phenyl)-5-methyl-thiazol-4-yl]-propoxy}-2-methyl-phenyl)-2-ethoxy-propionic acid ethyl ester was treated with LiOH to obtain [rac]-3-(4-{3-[2-(4-tert-butyl-phenyl)-5-methyl-thiazol-4-yl]-propoxy}-2-methyl-phenyl)-2-ethoxy-propionic acid as colorless liquid.

Workup

customdescribed in example 10 d

Sources & evidence

ORD record: ord-242d2939be844f688be755e4a5b7ffd4
Source dataset: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06809110B2

Reaction notes

Loading…