Lithium Hydroxide → (S)-3-{4-[2-(4-chloro-phenyl)-thiazol-4-ylmethoxy]-2,6-dimethyl-phenyl}-2-ethoxy-propionic acid

HRID 394357Notes

Reaction equation

C[O:2][C:3](=[O:31])[C@@H:4]([O:28][CH2:29][CH3:30])[CH2:5][C:6]1[C:11]([CH3:12])=[CH:10][C:9]([O:13][CH2:14][C:15]2[N:16]=[C:17]([C:20]3[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=3)[S:18][CH:19]=2)=[CH:8][C:7]=1[CH3:27].[Li+].[OH-]>>[Cl:26][C:23]1[CH:24]=[CH:25][C:20]([C:17]2[S:18][CH:19]=[C:15]([CH2:14][O:13][C:9]3[CH:10]=[C:11]([CH3:12])[C:6]([CH2:5][C@H:4]([O:28][CH2:29][CH3:30])[C:3]([OH:31])=[O:2])=[C:7]([CH3:27])[CH:8]=3)[N:16]=2)=[CH:21][CH:22]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 68617952HCID 68617952, compound

Product 1

HCID 68616451(S)-3-{4-[2-(4-chloro-phenyl)-thiazol-4-ylmethoxy]-2,6-dimethyl-phenyl}-2-ethoxy-propionic acid

Procedure

In analogy to the procedure described in example 10 d], (S)-3-{4-[2-(4-chloro-phenyl)-thiazol-4-ylmethoxy]-2,6-dimethyl-phenyl}-2-ethoxy-propionic acid methyl ester was treated with LiOH to obtain (S)-3-{4-[2-(4-chloro-phenyl)-thiazol-4-ylmethoxy]-2,6-dimethyl-phenyl}-2-ethoxy-propionic acid as light yellow solid.

Workup

customdescribed in example 10 d

Sources & evidence

ORD record: ord-ecaf68081ed047d084aea9e0e4805bc9
Source dataset: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06809110B2

Reaction notes

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