Lithium Hydroxide → HCID 22647517, compound

HRID 394362Notes

Reaction equation

C([O:3][C:4](=[O:33])[CH:5]([O:30][CH2:31][CH3:32])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][C:16]2[S:20][C:19]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[Cl:27])=[N:18][C:17]=2[CH3:28])=[CH:9][C:8]=1[CH3:29])C.[Li+].[OH-]>>[Cl:27][C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=1[C:19]1[S:20][C:16]([CH2:15][CH2:14][O:13][C:10]2[CH:11]=[CH:12][C:7]([CH2:6][CH:5]([O:30][CH2:31][CH3:32])[C:4]([OH:33])=[O:3])=[C:8]([CH3:29])[CH:9]=2)=[C:17]([CH3:28])[N:18]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 68616973HCID 68616973, compound

Product 1

HCID 22647517HCID 22647517, compound

Procedure

In analogy to the procedure described in example 10 d], [rac]-3-(4-{2-[2-(2-chloro-phenyl)-4-methyl-thiazol-5-yl]-ethoxy}-2-methyl-phenyl)-2-ethoxy-propionic acid ethyl ester was treated with LiOH to obtain [rac]-3-(4-{2-[2-(2-chloro-phenyl)-4-methyl-thiazol-5-yl]-ethoxy}-2-methyl-phenyl)-2-ethoxy-propionic acid as colorless liquid.

Workup

customdescribed in example 10 d

Sources & evidence

ORD record: ord-47eb03f39bd445ee893584ee42ca3528
Source dataset: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06809110B2

Reaction notes

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