Lithium Hydroxide → HCID 22647542, compound

HRID 394375Notes

Reaction equation

C([O:3][C:4](=[O:37])[CH:5]([O:34][CH2:35][CH3:36])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]([CH3:32])([C:16]2[S:20][C:19]([C:21]3[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][CH:22]=3)=[N:18][C:17]=2[CH3:31])[CH3:15])=[CH:9][C:8]=1[CH3:33])C.[Li+].[OH-]>>[CH2:35]([O:34][CH:5]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]([CH3:32])([C:16]2[S:20][C:19]([C:21]3[CH:22]=[CH:23][C:24]([C:27]([F:28])([F:29])[F:30])=[CH:25][CH:26]=3)=[N:18][C:17]=2[CH3:31])[CH3:15])=[CH:9][C:8]=1[CH3:33])[C:4]([OH:37])=[O:3])[CH3:36]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 68615542HCID 68615542, compound

Product 1

HCID 22647542HCID 22647542, compound

Procedure

In analogy to the procedure described in example 10 d], [rac]-2-ethoxy-3-(2-methyl-4-{1-methyl-1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethoxy}-phenyl)-propionic acid ethyl ester was treated with LiOH to obtain [rac]-2-ethoxy-3-(2-methyl-4-{1-methyl-1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethoxy}-phenyl)-propionic acid as colorless liquid.

Workup

customdescribed in example 10 d

Sources & evidence

ORD record: ord-ee0db236444f45dfa9309f12159aa843
Source dataset: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06809110B2

Reaction notes

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