HRID394389

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3939

Lithium hydroxide anhydrous

HLiO

结构：CCOC(=O)C(Cc1ccc(OC(c2ccccc2)c2sc(-c3ccc(C(F)(F)F)cc3)nc2C)cc1C)OCC

HCID68616165

未命名化合物

PRODUCTS

生成物

结构：CCOC(Cc1ccc(OC(c2ccccc2)c2sc(-c3ccc(C(F)(F)F)cc3)nc2C)cc1C)C(=O)O

HCID22647408

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described in example 10 d], 2-ethoxy-3-(2-methyl-4-{[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-phenyl-methoxy}-phenyl)-propionic acid ethyl ester (mixture of two diastereomeric racemates) was treated with LiOH to obtain 2-ethoxy-3-(2-methyl-4-{[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-phenyl-methoxy}-phenyl)-propionic acid as a mixture of two diastereomeric racemates as off-white gum.

WORKUP

后处理

customdescribed in example 10 d

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ba3e6519cc824013a055ad6254fb1030
来源数据集: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06809110B2
来源说明: uspto-grants-2004_10

反应 SMILES

C([O:3][C:4](=[O:41])[CH:5]([O:38][CH2:39][CH3:40])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH:14]([C:21]2[S:25][C:24]([C:26]3[CH:31]=[CH:30][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:28][CH:27]=3)=[N:23][C:22]=2[CH3:36])[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:9][C:8]=1[CH3:37])C.[Li+].[OH-]>>[CH2:39]([O:38][CH:5]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH:14]([C:21]2[S:25][C:24]([C:26]3[CH:31]=[CH:30][C:29]([C:32]([F:33])([F:34])[F:35])=[CH:28][CH:27]=3)=[N:23][C:22]=2[CH3:36])[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)=[CH:9][C:8]=1[CH3:37])[C:4]([OH:41])=[O:3])[CH3:40]