Potassium Iodide → HCID 68617948, compound

HRID 394395Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:19])[CH:4]([CH2:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][C:12]=1[CH3:18])[CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].Cl[CH2:21][C:22]1[S:26][C:25]([C:27]2[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:35])[F:34])=[CH:29][CH:28]=2)=[N:24][C:23]=1[CH3:37].C(=O)([O-])[O-].[Cs+].[Cs+].[I-].[K+]>>[CH3:1][O:2][C:3](=[O:19])[CH:4]([CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:21][C:22]2[S:26][C:25]([C:27]3[CH:28]=[CH:29][C:30]([C:33]([F:36])([F:34])[F:35])=[CH:31][CH:32]=3)=[N:24][C:23]=2[CH3:37])=[CH:13][C:12]=1[CH3:18])[CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

Participants

Reactant 4

HCID 4875Potassium Iodide

HCID 10796Cesium carbonate

HCID 27830065-Chloromethyl-4-methyl-2-(4-trifluoromethyl-phenyl)-thiazole

HCID 68617926[Rac]-2-(4-hydroxy-2-methyl-benzyl)-heptanoic acid methyl ester

Product 1

HCID 68617948HCID 68617948, compound

Procedure

In analogy to the procedure described in example 14 b], [rac]-2-(4-hydroxy-2-methyl-benzyl)-heptanoic acid methyl ester was reacted with 5-chloromethyl-4-methyl-2-(4-trifluoromethyl-phenyl)-thiazole [PCT Int. Appl. (2002), WO 0292590 A1] in the presence of cesium carbonate and potassium iodide to yield [rac]-2-{2-methyl-4-(4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-benzyl}-heptanoic acid methyl ester as colorless oil.

Sources & evidence

ORD record: ord-6d27bd5e813c4ae89808055ca1045bb4
Source dataset: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06809110B2

Reaction notes

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