HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → HCID 68617948, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 5-Chloromethyl-4-methyl-2-(4-trifluoromethyl-phenyl)-thiazole | HCID 2783006 | — |
| Reactant | [Rac]-2-(4-hydroxy-2-methyl-benzyl)-heptanoic acid methyl ester | HCID 68617926 | — |
| Product | HCID 68617948 | HCID 68617948 | — |
Reaction Steps
In analogy to the procedure described in example 14 b], [rac]-2-(4-hydroxy-2-methyl-benzyl)-heptanoic acid methyl ester was reacted with 5-chloromethyl-4-methyl-2-(4-trifluoromethyl-phenyl)-thiazole [PCT Int. Appl. (2002), WO 0292590 A1] in the presence of cesium carbonate and potassium iodide to yield [rac]-2-{2-methyl-4-(4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-benzyl}-heptanoic acid methyl ester as colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06809110B2 |
| Source dataset | uspto-grants-2004_10 |
| ORD ID | ord-6d27bd5e813c4ae89808055ca1045bb4 |
| Source note | uspto-grants-2004_10 |