Sodium Hydroxide → [Rac]-2-{2-methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-benzyl}-heptanoic acid

HRID 394396Notes

Reaction equation

C[O:2][C:3](=[O:36])[CH:4]([CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][C:19]2[S:23][C:22]([C:24]3[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][CH:25]=3)=[N:21][C:20]=2[CH3:34])=[CH:13][C:12]=1[CH3:35])[CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].[OH-].[Na+]>>[CH3:35][C:12]1[CH:13]=[C:14]([O:17][CH2:18][C:19]2[S:23][C:22]([C:24]3[CH:25]=[CH:26][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:28][CH:29]=3)=[N:21][C:20]=2[CH3:34])[CH:15]=[CH:16][C:11]=1[CH2:10][CH:4]([CH2:5][CH2:6][CH2:7][CH2:8][CH3:9])[C:3]([OH:36])=[O:2]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 68617948HCID 68617948, compound

Product 1

HCID 22647429[Rac]-2-{2-methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-benzyl}-heptanoic acid

Procedure

In analogy to the procedure described in example 10 d], [rac]-2-{2-methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-benzyl}-heptanoic acid methyl ester was treated with 3 N NaOH to obtain [rac]-2-{2-methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-benzyl}-heptanoic acid as yellow crystals.

Workup

customdescribed in example 10 d

Sources & evidence

ORD record: ord-fc4198e3faef417e867b579447fc4e24
Source dataset: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06809110B2

Reaction notes

Loading…