Lithium Hydroxide → HCID 22647405, compound

HRID 394398Notes

Reaction equation

C[O:2][C:3](=[O:39])[CH:4]([CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH:18]([CH:35]2[CH2:37][CH2:36]2)[C:19]2[S:23][C:22]([C:24]3[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][CH:25]=3)=[N:21][C:20]=2[CH3:34])=[CH:13][C:12]=1[CH3:38])[CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].[Li+].[OH-]>>[CH:35]1([CH:18]([C:19]2[S:23][C:22]([C:24]3[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][CH:25]=3)=[N:21][C:20]=2[CH3:34])[O:17][C:14]2[CH:15]=[CH:16][C:11]([CH2:10][CH:4]([CH2:5][CH2:6][CH2:7][CH2:8][CH3:9])[C:3]([OH:39])=[O:2])=[C:12]([CH3:38])[CH:13]=2)[CH2:37][CH2:36]1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 68616836HCID 68616836, compound

Product 1

HCID 22647405HCID 22647405, compound

Procedure

In analogy to the procedure described in example 10 d], 2-(4-{cyclopropyl-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-methoxy}-2-methyl-benzyl)-heptanoic acid methyl ester (mixture of two diastereomeric racemates) was treated with LiOH to obtain 2-(4-{cyclopropyl-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-methoxy}-2-methyl-benzyl)-heptanoic acid as a mixture of two diastereomeric racemates as colorless oil.

Workup

customdescribed in example 10 d

Sources & evidence

ORD record: ord-cd6d89386c28464087e909fb1c8b052a
Source dataset: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06809110B2

Reaction notes

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