Lithium Hydroxide → HCID 22647426, compound

HRID 394408Notes

Reaction equation

C[O:2][C:3](=[O:39])[CH:4]([O:34][CH2:35][CH2:36][CH2:37][CH3:38])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH:13]([CH:30]2[CH2:32][CH2:31]2)[C:14]2[S:18][C:17]([C:19]3[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=3)=[N:16][C:15]=2[CH3:29])=[CH:8][C:7]=1[CH3:33].[Li+].[OH-]>>[CH2:35]([O:34][CH:4]([CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH:13]([CH:30]2[CH2:31][CH2:32]2)[C:14]2[S:18][C:17]([C:19]3[CH:20]=[CH:21][C:22]([C:25]([F:27])([F:26])[F:28])=[CH:23][CH:24]=3)=[N:16][C:15]=2[CH3:29])=[CH:8][C:7]=1[CH3:33])[C:3]([OH:39])=[O:2])[CH2:36][CH2:37][CH3:38]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 68616525HCID 68616525, compound

Product 1

HCID 22647426HCID 22647426, compound

Procedure

In analogy to the procedure described in example 10 d], 2-butoxy-3-(4-{cyclopropyl-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-methoxy}-2-methyl-phenyl)-propionic acid methyl ester (mixture of two diastereomeric racemates) was treated with LiOH to obtain 2-butoxy-3-(4-{cyclopropyl-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-methoxy}-2-methyl-phenyl)-propionic acid as a mixture of two diastereomeric racemates as yellow liquid.

Workup

customdescribed in example 10 d

Sources & evidence

ORD record: ord-310ad2e416d94d72a9de1aa160c84929
Source dataset: uspto-grants-2004_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06809110B2

Reaction notes

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