Sodium → 4-Chloro-6-fluoro-2-methoxy-3-nitrophenylamine

Participants

Reaction Conditions

Reaction Steps

A suspension of 40.0 g (152 mmol) of N-(4-chloro-6-fluoro-2-methoxy-3-nitrophenyl)acetamide in 800 ml of 6M hydrochloric acid was heated for 5 hours at reflux temperature, whereupon the mixture was stirred overnight at approximately 20° C. For work-up, the reaction mixture was stirred into ice-water. The pH was brought to 8-9 by adding sodium solution. The mixture was subsequently extracted six times with ethyl acetate. The combined organic phases were dried over magnesium sulfate and then concentrated under reduced pressure. Yield: 33 g (98%);

Provenance & Evidence