反应详情

温度

20 °C

A suspension of 40.0 g (152 mmol) of N-(4-chloro-6-fluoro-2-methoxy-3-nitrophenyl)acetamide in 800 ml of 6M hydrochloric acid was heated for 5 hours at reflux temperature, whereupon the mixture was stirred overnight at approximately 20° C. For work-up, the reaction mixture was stirred into ice-water. The pH was brought to 8-9 by adding sodium solution. The mixture was subsequently extracted six times with ethyl acetate. The combined organic phases were dried over magnesium sulfate and then concentrated under reduced pressure. Yield: 33 g (98%);

1. temperaturewas heated for 5 hours
2. temperatureat reflux temperature
3. extractionThe mixture was subsequently extracted six times with ethyl acetate
4. dry with materialThe combined organic phases were dried over magnesium sulfate
5. concentrationconcentrated under reduced pressure