Hydrogen Peroxide → HCID 18176466, compound

HRID 394449Notes

Reaction equation

HRID 394449 reaction equation
[CH2:1]([CH:8]1[NH:14][CH2:13][CH2:12][S:11](=[O:15])[C:10]2[C:16](=[O:21])[N:17]([CH3:20])[N:18]=[CH:19][C:9]1=2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:22]O>C(O)(=O)C>[CH2:1]([CH:8]1[NH:14][CH2:13][CH2:12][S:11](=[O:22])(=[O:15])[C:10]2[C:16](=[O:21])[N:17]([CH3:20])[N:18]=[CH:19][C:9]1=2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 18176452HCID 18176452, compound

Product 1

HCID 18176466HCID 18176466, compoundYield 55%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 0.60 g (1.98 mmol) of 5-benzyl-8-methyl-2,3,4,5-tetrahydro-9(8H)-pyridazino[4,5-b][1,5]thiazepinone-1-oxide, 1.92 ml of glacial acetic acid and 1.2 ml of 30% aqueous hydrogen peroxide are left to stand for a day. The precipitated crystals are filtered, washed acid free with water and dried in an exsiccator. In this way 0.35 g (55%) of the title compound are obtained with a melting point of 288-290° C.

Workup

  1. waitare left
  2. waitto stand for a day
  3. filtrationThe precipitated crystals are filtered
  4. washwashed acid free with water
  5. customdried in an exsiccator

Sources & evidence

ORD record
ord-68b19e72d8f44c5096c439641e401457
Source dataset
uspto-grants-2003_08
Patent number
US06602865B1

Reaction notes

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