反应详情

A solution of Compound 4 (27.1 g, 64 mmol) and dioxane (500 mL) were stirred under argon. Hydrochloric acid (6N, 250 mL) was added dropwise using an addition funnel. After 3d dioxane was removed in vacuo. The remaining aqueous mixture was extracted exhaustively with methylene chloride. The combined organic extracts were dried over anhydrous sodium sulfate then the solvent was removed in vacuo to give a yellow oil. Hexane followed by ether was added to afford a solid (5) which was isolated by vacuum filtration: 18.6 g (50.4 mmol, 79%)

1. customAfter 3d dioxane was removed in vacuo
2. extractionThe remaining aqueous mixture was extracted exhaustively with methylene chloride
3. dry with materialThe combined organic extracts were dried over anhydrous sodium sulfate
4. customthe solvent was removed in vacuo
5. customto give a yellow oil
6. additionwas added